Sanjeev Gupta

Dr Sanjeev Gupta


Career History

Senior Research Fellow, National university of Ireland, Galway, 2007

Postdoctoral fellow, Thomas Jefferson University (TJU), Philadelphia 2003

Ph.D Jawaharlal Nehru University, New Delhi, India, 2002

M.Sc. Hamdard University, New Delhi, India, 1996


Research Interests


Regulators and mediators of the ER stress response

miRNA regulation of stress responses


Research Overview


A class of small RNAs, known as microRNAs (miRNAs), are critically involved in control of cell survival and cell death decisions. The main function of miRNAs is to direct posttranscriptional regulation of gene expression, typically by binding to 3’ UTR of cognate mRNAs. Our main goal is to evaluate the role of microRNAs in determining cell fate during conditions of ER stress. ER stress has been associated with a wide range of diseases, including neurodegeneration, stroke, bipolar disorder, cardiac disease, cancer, and diabetes. Identification of microRNAs involved in cellular response to ER-stress will reveal a level of molecular control that is well beyond the classical role of signaling pathways mediated by protein phosphorylation.


Selection of key publications:


Samali A, FitzGerald U, Deegan S, Gupta S (2010) Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response. Int J Cell Biol Article ID 830307, 11 pages (senior author)


Gupta S, Cuffe L, Szegezdi E, Logue SE, Neary C, Healy S, Samali A (2010) Mechanisms of ER stress-mediated mitochondrial membrane permeabilization. Int J Cell Biol In press.


Healy SJ, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009). Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Eur J Pharmacol. Dec 25;625(1-3):234-46.


Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A (2009) Bcl-2 family on guard at the ER. Am J Physiol Cell Physiol. May;296(5):C941-53.


Gupta S, Kass GE, Szegezdi E, Joseph B (2009) The mitochondrial death pathway: A promising therapeutic target in Diseases. J Cell Mol Med.13: 6: 1004-1033


Hu S, Du M-Q, Park S-M, Alcivar A, Qu L, Gupta S, Tang J, Baens M, Ye H, Lee TH, Marynen P, Riley JL, Yang X (2006) cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin. Invest. 116(1)174-181.


Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (2005) Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Oncogene 24: 627-636


*Jain N…, Gupta S…, Sudhakar Ch, Radha V, Swarup G (2005) Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin. J Biol Chem. Nov 4;280(44):36664-73. …Equal contribution


Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS (2004) Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem. 2004 Nov 26;279(48):50295-301.


*Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, DuBois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2004) The carboxy terminal tail of Presenilin regulates Omi/HtrA2 protease activity. J. Biol. Chem. 279(44):45844-54


Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES (2003) Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. J Biol Chem. 78:31469-31472


Jones JM, Datta P, Srinivasula SM, Weizhen J, Gupta S, Zhang Z, Saunders TL, Margaret L. Van Keuren, Fernandes-Alnemri T, Alnemri ES (2003) Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice. Nature. 425: 721-7.


* Gupta S, Radha V, Sudhakar Ch, Swarup G (2002) A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Letters. 532, 61-66.


Ganapati U, Gupta S, Radha V, Manogaran PS, Swarup G (2001) A Nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-myc protein level. Exp.Cell Res. 265,1-10.


*Gupta S, Radha V, Furukawa Y, Swarup G (2001) Transcriptional activation of human caspase-1 by tumor suppressor p53. J. Biol. Chem. 276, 10585-10588.

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